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These experiments provide a robust demonstration that GSSSG and LASSS treatment of HGF prevents peroxynitrite-induced Y198/Y250-nitration/dysfunction of HGF, and thus guarantee satellite cell activation activity

The progressive degeneration or dysfunction of RPE cells, which is a hallmark of multiple retinal disorders, invariably causes vision loss or even permanent blindness due to the absence of regenerative capacity (80) ( Table 1 )

Conversely, 6-TGNs were only associated with leukopenia in patients with IBD with NUDT15 nonvariants but not in patients with NUDT15 variants